SARS Vaccine Development
Identifieur interne : 004665 ( Main/Exploration ); précédent : 004664; suivant : 004666SARS Vaccine Development
Auteurs : Shibo Jiang [États-Unis] ; Yuxian He [États-Unis] ; Shuwen Liu [États-Unis]Source :
- Emerging Infectious Diseases [ 1080-6040 ] ; 2005.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , immunology : Membrane Glycoproteins, Viral Envelope Proteins.
- chemical : Epitopes, Spike Glycoprotein, Coronavirus, Vaccines, Inactivated, Viral Vaccines.
- immunology : SARS Virus.
- prevention & control : Severe Acute Respiratory Syndrome.
- Humans.
Abstract
Developing effective and safe vaccines is urgently needed to prevent infection by severe acute respiratory syndrome (SARS)–associated coronavirus (SARS-CoV). The inactivated SARS-CoV vaccine may be the first one available for clinical use because it is easy to generate; however, safety is the main concern. The spike (S) protein of SARS-CoV is the major inducer of neutralizing antibodies, and the receptor-binding domain (RBD) in the S1 subunit of S protein contains multiple conformational neutralizing epitopes. This suggests that recombinant proteins containing RBD and vectors encoding the RBD sequence can be used to develop safe and effective SARS vaccines.
Url:
DOI: 10.3201/eid1107.050219
PubMed: 16022774
PubMed Central: 3371787
Affiliations:
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Le document en format XML
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